Fibrinogen (factor I) is a blood plasma glycoprotein essential for clot formation. Upon injury, thrombin
converts fibrinogen to fibrin, aiding in blood clot development. Fibrin also plays roles in:

• Platelet and endothelial cell adhesion
• Fibroblast activity
• Capillary tube formation
• Wound healing and angiogenesis

Alterations in fibrinogen levels or structure (due to disorders like afibrinogenemia, CKD, or amyloidosis)
can lead to abnormal bleeding, thrombosis, or fibrinogen deposits in tissues.