INI-1

ZR282/Rabbit/Monoclonal

Gene Bio Solution INI-1 Antibody. Gene Bio Solution’s recombinant rabbit antibody recognizes INI-1, a core subunit of the adenosine triphosphate (ATP) dependent SWI and SNF chromatin remodeling complex, which is actively involved in the regulation of gene expression. The INI-1 gene has been found to be a tumor suppressor, which is often mutated or deleted in malignant rhabdoid tumors, epithelioid sarcoma, and some malignant peripheral nerve sheath (MPNST) tumors.

The INI-1 protein (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1) encoded by the SMARCB1 gene. The INI-1 protein is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively.

The INI-1 is a tumor supressor where loss of function is associated with rhabdoid tumor predisposition syndrome 1 and familial schwannomatosis and has been identified in a variety of rhabdoid and nonrhabdoid neoplasms of the CNS, soft tissue and parenchymal and visceral organs. Additionally, INI-1 loss of expression contributes to malignant rhabdoid tumor of kidney and soft tissue and CNS atypical teratoid or rhabdoid tumor and renal medullary carcinoma. INI-1 loss of function is found in sinonasal carcinoma or adenocarcinoma and undifferentiated and rhabdoid carcinoma of the gastrointestinal tract and pancreas.

Gene Bio Solution is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.

Specifications

Species Reactivity

Humans; others not tested

Known Applications

Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As

Buffer with protein carrier and preservative

Storage

Store at 2ºC to 8ºC

Control

Epithelioid sarcoma

Visualization

Nuclear

Isotype

IgG

Immunogen

Full-length human BAF47 protein

Ordering Information

Format:

Volume:

  • Classification
  • RUO
  • Catalogue Number
  • G2597RP

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