The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Rabbit
IgG
Affinity purification
Store at 2ºC to 8ºC
92kDa
85kDa
SMab Recombinant Monoclonal Antibody.
WB,IHC-P,IF/ICC,IP,ELISA
Human,Mouse,Rat
GR0136
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human beta Catenin (P35222).
EVR7; CTNNB; MRD19; NEDSDV; armadillo; in
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