Fighting Cancer, One Slide at a Time

talk to us

Genebiosolution > IHC Primary Antibody > ACTH (Adrenocorticotrophic Hormone)

ACTH (Adrenocorticotrophic Hormone)

Clone 57 (Concentrate)

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue specific, posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropinlike intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin, and Metenkephalin. ACTH is also produced by cells of the immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress.

Datasheet Make Enquiry

Specifications

Species

Mouse

Immunogen

N-terminal fragment of human ACTH conjugated to KLH

Clone

Isotype

IgG1, kappa

Species Reactivity

Human and Rat. Expected to show a broad species reactivity.

Positive Control

Normal pituitary gland or pituitary tumor.

Specificity

This antibody is specific to Synacthen (aa 1-24 of ACTH); this antibody does not react with CLIP (aa 17-39 of ACTH). Anti-ACTH is a useful marker in classification of pituitary tumors and in the study of pituitary disease.

Cellular Localization

Cytoplasmic

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G0266RP

At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.