ACTH (Adrenocorticotrophic Hormone)

Clone: AH26+57

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific, posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropinlike intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin, and Metenkephalin. ACTH is also produced by cells of the immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress.

Specifications

Species

Mouse

Immunogen

Synthetic peptide corresponding to aa 1-24 of human ACTH (AH26); N-terminal fragment of human ACTH conjugated to KLH (57).

Clone

AH26 & 57

Isotype

IgG1, kappa (AH26); IgG1, kappa (57).

Species Reactivity

Human, Mouse, and Rat. Expected to show a broad species reactivity.

Positive Control

Normal pituitary gland or pituitary tumor.

Specificity

This antibody is specific to Synacthen (aa 1-24 of ACTH); this antibody does not react with CLIP (aa 17-39 of ACTH). Anti-ACTH is a useful marker in classification of pituitary tumors and in the study of pituitary disease.

Cellular Localization

Cytoplasmic