Actin, Muscle Specific (MSA)
HHF35/Mouse/Monoclonal
The Actin Muscle Specific (MSA) Antibody, clone HHF35, is a mouse monoclonal antibody specifically developed for the detection of muscle-specific actins found in smooth, cardiac, and skeletal muscle tissues. Recognizing both α and γ isoforms of actin, clone HHF35 is widely used in immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissue sections to assess muscle differentiation and identify muscle-derived tumors.
HHF35 is a key diagnostic marker in the evaluation of soft tissue tumors, including leiomyomas, leiomyosarcomas, rhabdomyomas, and rhabdomyosarcomas, as well as in distinguishing myogenic components in mixed or poorly differentiated neoplasms. It provides strong, diffuse cytoplasmic staining in muscle cells, and can also label myofibroblasts, offering additional utility in examining stromal reactions, fibrotic processes, and desmoplastic responses in carcinomas.
Due to its broad reactivity across multiple muscle types, the MSA antibody (HHF35) is ideal for use in oncology, cardiovascular research, muscle pathology, and tumor classification. It performs consistently across a wide range of tissue types and is compatible with manual and automated IHC platforms.
With its robust staining pattern and diagnostic reliability, clone HHF35 is a valuable tool for pathologists and researchers requiring precise detection of muscle-specific actin in both benign and malignant settings.
