Actin, Smooth Muscle (Leiomyosarcoma Marker)

Clone 1A4 (Concentrate)

Actin, Smooth Muscle (Leiomyosarcoma Marker), clone 1A4 is a monoclonal antibody that specifically recognizes smooth muscle actin (SMA), an actin isoform predominantly found in smooth muscle cells. This antibody, clone 1A4, binds to the alpha-smooth muscle actin protein, a key component of the cytoskeleton involved in cellular contractility. It is widely used in immunohistochemistry to identify smooth muscle differentiation in both normal tissues and neoplastic conditions. Its diagnostic utility is particularly valuable in distinguishing leiomyosarcoma from other soft tissue tumors, as leiomyosarcomas typically show strong and diffuse cytoplasmic staining for SMA. Additionally, this marker can be helpful in identifying myofibroblasts in reactive and fibrotic processes, as well as in certain vascular tumors. Clone 1A4 is considered a reliable tool for pathology labs due to its specificity and consistent staining patterns.

Specifications

Species

Mouse

Immunogen

N-terminal decapeptide of alpha smooth muscle isoform of actin and conjugated to KLH.

Clone

1A4

Isotype

IgG2a, kappa

Species Reactivity

Human, Baboon, Monkey, Cow, Pig, Sheep, Goat, Cat, Dog, Rabbit, Mouse, Rat, Guinea Pig and Chicken. Others not known.

Positive Control

Blood vessels in all tissues, smooth muscle or leiomyosarcoma.

Specificity

This MAb is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids.

Cellular Localization

Cytoplasmic

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