The ALK Protein , Clone ALK-1, is a highly specific and sensitive antibody designed for the detection of anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase implicated in various cancers, including anaplastic large cell lymphoma, non-small cell lung carcinoma, and neuroblastoma. ALK plays a critical role in cell growth and differentiation, making it an essential biomarker and therapeutic target in oncology. Clone ALK-1 delivers consistent and robust staining with high affinity for the ALK protein, enabling precise identification of ALK expression in human tissues. This antibody is extensively validated for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues, as well as Western blotting (WB) and flow cytometry (FC), providing versatility for both research and clinical applications. Ideal for cancer diagnostics and translational research, ALK-1 enables pathologists and researchers to accurately detect ALK rearrangements and protein expression levels, facilitating diagnosis, prognosis, and treatment planning. The antibody exhibits minimal background and high reproducibility, ensuring reliable results across multiple experiments. Manufactured using hybridoma technology and affinity-purified, this mouse monoclonal antibody offers excellent lot-to-lot consistency and long-term stability for routine laboratory use. Key Features: Clone: ALK-1 Host / Isotype: Mouse / IgG1 Target: Anaplastic Lymphoma Kinase (ALK) Reactivity: Human Applications: Immunohistochemistry (IHC), Western Blot (WB), Flow Cytometry (FC) Sample Types: FFPE tissues, frozen sections, cell lysates Purification: Affinity-purified Storage: Store at −20°C; avoid repeated freeze-thaw cycles Research and Clinical Applications: Detection of ALK expression in lymphomas, lung cancers, and neuroblastomas Diagnosis and subclassification of anaplastic large cell lymphoma (ALCL) Biomarker analysis in targeted cancer therapies Study of ALK gene rearrangements and fusion proteins Translational and personalized oncology research
ALK-1
ALK-1 reacts to human total ALK protein including ALK fusion proteins
A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase)
Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
