Anti-CD1a Rabbit Monoclonal Antibody

Product Overview

The Anti-CD1a Rabbit Monoclonal Antibody Clone RM393 is a high-affinity, recombinant IgG antibody designed for precise detection of human T-cell surface glycoprotein CD1a. CD1a is a non-polymorphic, MHC class I-related glycoprotein expressed on cortical thymocytes, epidermal Langerhans cells, and dendritic cells, playing a crucial role in presenting lipid and glycolipid antigens to T lymphocytes. It is also a key marker for diagnosing Langerhans cell histiocytosis (LCH). This antibody is purified using Protein A affinity chromatography from an animal origin-free culture supernatant, ensuring high purity and specificity. It is supplied in a liquid form with a storage buffer containing PBS, 50% glycerol, 1% BSA, and 0.09% sodium azide. The recommended dilution for immunohistochemistry (IHC) applications is 1:100 to 1:200, and the antibody is stable for 12 months when stored at -20°C. The RM393 clone is particularly useful for identifying abnormal proliferation of Langerhans cells and contributes to the diagnosis of Langerhans cell histiocytosis (LCH) . It is suitable for research applications and is not intended for diagnostic or therapeutic use.