CDX2 Antibody (Rabbit Monoclonal) – Highly Specific Nuclear Marker for Intestinal Differentiation and Colorectal Cancer Diagnostics The CDX2 Antibody (Rabbit Monoclonal) is a highly sensitive and specific tool designed for the detection of Caudal Type Homeobox 2 (CDX2), a nuclear transcription factor that plays a vital role in the regulation of intestinal epithelial cell development, differentiation, and maintenance. CDX2 is expressed predominantly in the nuclei of intestinal epithelial cells from the duodenum to the rectum and is critically involved in the transcriptional control of genes specific to the gastrointestinal tract. This recombinant rabbit monoclonal antibody provides consistent and robust nuclear staining, making it an ideal marker for identifying primary and metastatic colorectal adenocarcinomas, as well as differentiating tumors of gastrointestinal origin from those of other epithelial tissues. CDX2 expression is retained in a majority of colorectal cancers and serves as a key component in diagnostic IHC panels, especially when determining the tissue origin of metastatic carcinomas of unknown primary (CUP). Additionally, it is valuable in identifying intestinal metaplasia and can be used in studies focused on developmental biology, tumor progression, and gastrointestinal tract morphogenesis. 🔬 Clinical and Research Applications: Colorectal Cancer Diagnosis: CDX2 is a reliable immunohistochemical marker for primary and metastatic colorectal adenocarcinomas, helping to establish tumor origin with high sensitivity and specificity. Metastatic Tumor Origin Identification: Aids in distinguishing GI-derived cancers from pancreatic, lung, ovarian, and other non-GI adenocarcinomas. Pathological Evaluation of GI Lesions: Useful in assessing intestinal metaplasia, Barrett’s esophagus, and adenomatous changes in the gastrointestinal tract. Prognostic Marker: Loss of CDX2 expression has been correlated with poor prognosis and aggressive tumor behavior in colorectal cancer. Developmental Studies: Enables investigation of intestinal epithelial lineage and homeobox gene regulation during embryogenesis.
GRM495
This antibody reacts to human CDX2.
Recombinant human CDX2 protein.
Immunohistochemistry (IHC)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
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