Cytokeratin 7 (CK-7)Antibody Mouse Monoclonal

Cytokeratin 7 (CK-7) Antibody Mouse Monoclonal

The Cytokeratin 7 (CK7) Mouse Monoclonal Antibody [Clone OV-TL 12/30] is a high-affinity, highly specific reagent designed for the immunohistochemical detection of CK7, a type II intermediate filament protein expressed in a wide range of glandular and transitional epithelial tissues. CK7 is a key epithelial marker involved in the structural integrity of cytoskeletal networks and is commonly used in diagnostic immunohistochemistry to distinguish various carcinomas based on their cytokeratin expression profiles. This antibody is validated for use on formalin-fixed, paraffin-embedded (FFPE) tissue sections and provides strong cytoplasmic staining with minimal background, offering superior performance in routine and advanced pathology workflows. Clone OV-TL 12/30 has been widely adopted for identifying CK7-positive tumors, including lung adenocarcinomas, ovarian serous carcinomas, endometrial carcinomas, breast carcinomas, and transitional cell carcinomas. It is especially useful when used in combination with CK20 antibody to aid in the differential diagnosis of metastatic carcinomas, helping distinguish between primary and secondary tumors of unknown origin. The antibody demonstrates consistent and reproducible results, making it an essential tool in histopathology laboratories for both clinical diagnosis and tumor classification. CK7 expression is typically absent in colorectal carcinomas and prostate cancers, making this marker valuable in tissue origin determination. The antibody’s robust staining characteristics and high specificity ensure precise localization of CK7-positive cells, improving diagnostic confidence and supporting accurate tumor typing and patient management. This monoclonal antibody is supplied in a ready-to-use or concentrated format and is compatible with a wide range of detection systems.