The Gamma-H2AX (Phospho-Ser139) Antibody (Rabbit Monoclonal) from GeneBioSolution is a high-performance antibody optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues. Histone H2AX is a variant of the histone H2A family, and its phosphorylation at serine 139 (γH2AX) is one of the earliest cellular responses to DNA double-strand breaks (DSBs). This antibody provides sensitive and specific nuclear staining of γH2AX, enabling reliable detection of DNA damage and repair activity. It is a critical tool in cancer research, radiation biology, and genotoxicity testing. γH2AX expression is widely used as a biomarker for genomic instability, tumor progression, and therapeutic response to radiation and chemotherapy. Beyond oncology, this antibody is also valuable for research into aging, neurodegeneration, and environmental stress responses, where DNA damage plays a key role. All GeneBioSolution antibodies undergo rigorous validation and quality control, ensuring lot-to-lot consistency, high specificity, and reproducible performance on both manual and automated IHC platforms. Clinical & Research Applications Biomarker of DNA double-strand breaks in tissue sections Research on cancer progression, genomic instability, and DNA repair pathways Evaluation of radiation therapy and chemotherapy responses Genotoxicity and drug safety studies Studies on aging, neurodegeneration, and stress-induced DNA damage Key Features Clone: Rabbit Monoclonal, phospho-specific to Ser139 Application: Immunohistochemistry (IHC) on FFPE tissues Target Protein: γH2AX (Phosphorylated Histone H2AX at Ser139) Diagnostic/Research Utility: DNA damage detection, cancer research, radiation biology Performance: Strong nuclear staining, high specificity, reproducible results
GRM224
GRM224 reacts to Histone H2A.X only when phosphorylated at serine 139. No cross reactivity with other phosphorylated histones.
A phospho-peptide corresponding to Phospho-Histone H2AX (Ser139).
Western Blot (WB) Immunocytochemistry (ICC) Immunohistochemistry (IHC) ELISA Multiplex
Human Vertebrates
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
