Anti-Histone H3 K9M Antibody

Anti-Histone H3 K9M Rabbit Monoclonal Antibody

Anti-Histone H3 K9M Rabbit Monoclonal Antibody (Clone RM191) – Mutation-Specific | IHC & Western Blot The Anti-Histone H3 K9M Rabbit Monoclonal Antibody (Clone RM191) is a mutation-specific, high-affinity antibody engineered to selectively detect the lysine-to-methionine substitution at position 9 (K9M) in Histone H3. This rare oncogenic mutation is associated with aberrant chromatin remodeling and is frequently observed in pediatric gliomas and other epigenetically driven tumors. RM191 is specifically designed to bind only the H3 K9M mutant, with no cross-reactivity to wild-type H3 or other histone mutations such as H3 K27M, ensuring precise and accurate detection in mutation-focused cancer research and diagnostics. Key Features: Clone: RM191 | Host: Rabbit | Format: Recombinant Monoclonal Specificity: H3 K9M mutant only No Cross-Reactivity: Wild-type H3 or H3 K27M Applications: Immunohistochemistry (IHC) on FFPE tissues Western Blotting (WB) Target: Histone H3 K9M mutation (Lysine 9 to Methionine) Validated For: Human tissue samples, cancer models Application Areas: Pediatric Glioma Research , Epigenetic Biomarker Detection , Tumor Mutation Profiling , Chromatin Remodeling Studies Ultra-specific for H3 K9M epigenetic mutation Ideal for mutation-specific diagnostics and cancer research No background staining from wild-type histone proteins. Validated on FFPE sections and immunoblot assays