The Anti-Histone MacroH2A1/MacroH2A2 Rabbit Monoclonal Antibody (Clone GRM248) specifically recognizes the histone variants MacroH2A1 and MacroH2A2, unique components of chromatin associated with transcriptional repression and chromatin compaction. MacroH2A histones differ from canonical H2A by the presence of a large C-terminal macro domain, playing crucial roles in X-chromosome inactivation, gene regulation, and cellular differentiation.
GRM248
GRM248 reacts to the Core histone macro-H2A.1 and macro-H2A.2 proteins, independent of post-translational modifications. No cross reactivity with other histone proteins.
A peptide corresponding to the C-terminus of human Histone macroH2A1.
Western Blot (WB) Immunocytochemistry (ICC) ELISA Multiplex
Human Vertebrates
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt