The Phospho-EGFR (Tyr1068) Rabbit Monoclonal Antibody from GeneBioSolution is a high-performance antibody designed for immunohistochemistry (IHC) and related applications on formalin-fixed, paraffin-embedded (FFPE) tissues. EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase that regulates cell proliferation, differentiation, and survival. Dysregulation of EGFR activity is linked to the development of several cancers. Phosphorylation at Tyr1068 is a critical activation site within EGFR that mediates downstream signaling through pathways such as RAS/RAF/MEK/ERK and PI3K/AKT. This antibody provides sensitive and specific detection of EGFR phosphorylated at Tyr1068, allowing researchers and pathologists to evaluate EGFR activation status in tumor samples. It is a valuable biomarker in assessing oncogenic signaling, tumor aggressiveness, and response to EGFR-targeted therapies such as tyrosine kinase inhibitors (TKIs). Clinical & Research Applications Evaluation of EGFR signaling activation in cancer tissues Detection of EGFR phosphorylation at Tyr1068 by IHC Biomarker for non-small cell lung carcinoma (NSCLC), colorectal cancer, breast carcinoma, and glioblastomas Research on drug resistance and targeted therapy response Pathway studies involving cell proliferation and survival mechanisms
GRM443
GRM443 reacts to human EGF Receptor only when phosphorylated at Tyr1068.
A phospho-peptide corresponding to human Phospho- EGFR (Tyr1068)
WB
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
