The Phospho-GSK-3β (Ser9) Rabbit Monoclonal Antibody (Clone GRM453) specifically detects GSK-3β protein phosphorylated at serine 9, a key regulatory modification that inhibits kinase activity. GSK-3β is a multifunctional serine/threonine kinase involved in numerous signaling pathways, including Wnt/β-catenin, insulin, and cell cycle regulation. The phosphorylation at Ser9 is critical for controlling GSK-3β function in processes such as glycogen metabolism, cell proliferation, and apoptosis. Clone GRM453 is ideal for detailed studies of GSK-3β regulation in normal physiology and disease contexts such as cancer, diabetes, and neurodegeneration.
GRM453
GRM453 reacts to human GSK-3β only when phosphorylated at Ser9. There is no cross-reactivity to GSK-3β that is not phosphorylated. This antibody may also react to mouse or rat Phospho- GSK-3β (Ser9) as predicted by immunogen homology.
A phospho-peptide corresponding to human Phospho-GSK-3β (Ser9)
Immunohistochemistry (IHC), Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
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