The Prostate Specific Antigen (PSA) Antibody, Clone EP109 (Rabbit Monoclonal) is a highly specific reagent for the detection of PSA/KLK3 (kallikrein-related peptidase 3), a 34 kDa serine protease secreted by prostatic epithelial cells and regulated by the androgen receptor (AR) signaling axis. PSA is a lineage-restricted biomarker of prostatic differentiation and remains the most widely used immunohistochemical marker for establishing prostatic origin in both primary adenocarcinomas and metastatic lesions. Clone EP109, derived as a rabbit monoclonal, offers superior antigen recognition, high affinity binding, and reduced background compared to traditional mouse monoclonals, enabling precise and reproducible cytoplasmic staining in formalin-fixed paraffin-embedded (FFPE) tissues. Its enhanced sensitivity makes it particularly valuable in cases of poorly differentiated prostate carcinoma, where morphological assessment and conventional markers may be insufficient. From a clinical perspective, PSA immunodetection with EP109 plays a pivotal role in differentiating metastatic prostate carcinoma from morphologically similar malignancies, including urothelial carcinoma, colorectal carcinoma, and hepatocellular carcinoma. Beyond diagnostics, PSA serves as a critical surrogate for androgen receptor pathway activity, and EP109 is widely applied in research investigating androgen dependence, castration-resistant prostate cancer (CRPC), tumor progression, and therapeutic resistance mechanisms.
GRM323
GRM323 reacts to native human PSA (Prostate Specific Antigen), including both free (unbound) form and in a complex with ACT (alpha 1-antichymotrypsin). It may react to reduced PSA at a higher concentration.
Native PSA protein purified from human seminal fluid.
Immunohistochemistry (IHC) Western Blot (WB-Non-Reduced) ELISA
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
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