The PSD95 Antibody (Rabbit Monoclonal) is a highly specific reagent for the detection of Postsynaptic Density Protein 95 (PSD95, also known as DLG4), a 95 kDa scaffolding protein that is a major constituent of the postsynaptic density in excitatory neurons. PSD95 belongs to the membrane-associated guanylate kinase (MAGUK) family and contains multiple PDZ, SH3, and guanylate kinase-like domains, enabling it to orchestrate the assembly of multiprotein complexes at the postsynaptic membrane. Through interactions with NMDA receptors (NR2 subunits), AMPA receptors, potassium channels, neuroligins, and signaling molecules such as nNOS, PSD95 is central to synaptic signal transduction, plasticity, and receptor trafficking. Expression of PSD95 is restricted primarily to neurons within the central nervous system, where it is enriched in the cerebral cortex, hippocampus, striatum, and cerebellum. Its abundance and localization make it a widely accepted biomarker for excitatory synapse density and maturation. Dysregulation of PSD95 has been linked to multiple neuropathological conditions, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, epilepsy, schizophrenia, autism spectrum disorders, and ischemic brain injury, highlighting its translational value in both research and clinical contexts.
GRM288
GRM288 reacts to human and mouse PSD95. It may also react to rat PSD95, as predicted by immunogen homology
A peptide corresponding to the N-terminus of human PSD95
Immunohistochemistry (IHC) Western Blot (WB)
Human, Mouse (Rat)
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
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