S100 Beta Antibody (Rabbit Monoclonal, Clone EP32) is a rigorously validated monoclonal antibody designed for the precise detection of the S100β protein, a homodimeric calcium-binding protein of the EF-hand family encoded by the S100B gene on chromosome 21q22.3. S100β is predominantly localized in astrocytes, Schwann cells, and melanocytes, where it functions as a regulator of intracellular calcium flux, cytoskeletal organization, protein phosphorylation, and transcriptional activity. Extracellularly, S100β exerts trophic or toxic effects in a concentration-dependent manner, influencing neuroinflammation, gliosis, and tumor progression. Clone EP32 demonstrates exceptional affinity and epitope specificity, ensuring reproducible and high-contrast nuclear and cytoplasmic immunoreactivity in formalin-fixed paraffin-embedded (FFPE) tissues. Its robust staining performance in immunohistochemistry (IHC) establishes it as a key diagnostic biomarker for astrocytic gliomas, schwannomas, ependymomas, and malignant melanoma, where S100β expression serves as a hallmark of neural crest differentiation. This antibody is also suitable for Western blotting and ELISA, enabling quantitative and qualitative assessment of S100β expression in both clinical and experimental settings. Due to its high sensitivity, clone EP32 is extensively employed in neuropathology and oncologic diagnostics for tumor classification, lineage tracing, and biomarker validation. The antibody provides pathologists and researchers with a reliable tool to investigate S100β-mediated mechanisms in neuro-oncology, neurodegeneration, and calcium signaling–dependent cellular pathways.
GRM304
GRM304 reacts to human S100-B (S-100 protein beta chain). It may also react to mouse or rat S100-B, as predicted by immunogen homology.
A peptide corresponding to the C-terminus of human S100-B
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
