Anti-Trimethyl-Histone H3 (Lys27) Rabbit Monoclonal Antibody

H3K27me3 is a hallmark of gene silencing and is catalyzed by the Polycomb Repressive Complex 2 (PRC2). It plays a central role in regulating gene expression during embryogenesis, X-chromosome inactivation, and cellular differentiation. Aberrant patterns of H3K27me3 are linked to tumorigenesis, stem cell dysregulation, and epigenetic plasticity in cancer. GRM175 provides researchers with a precise tool to study this key histone mark in normal and diseased states.

Specifications

Clone Name

GRM175

Specificity

GRM175 reacts to Histone H3 trimethylated at Lysine 27 (K27me3). No cross reactivity non-modified Lysine 27, monomethylated Lysine 27 (K27me1) or dimethylated Lysine 27 (K27me2), or other methylations in histone H3.

Immunogen

A trimethyl-peptide corresponding to trimethyl-Histone H3 (Lys27).

Application

Chromatin IP (ChIP) Western Blot (WB) Immunohistochemistry (IHC) ELISA Multiplex

Species Reactivity

Human Vertebrates

Conjugate

None

Intended Use

Research Use Only

Storage and Stability:

Stable for 1 Year at -20.0°C from date of receipt.