Bax (Bcl-2-associated X protein) is a pro-apoptotic member of the Bcl-2 protein family that plays a key role in the regulation of programmed cell death (apoptosis). It promotes apoptosis by translocating to the mitochondria, where it contributes to the release of cytochrome c and activation of the caspase cascade. The Bax antibody, Clone 2D2, is a monoclonal antibody specifically designed to detect the Bax protein in various applications, including Western blotting, immunohistochemistry, and flow cytometry. This clone offers high specificity and sensitivity, making it a valuable tool for studying apoptotic pathways in both normal and pathological conditions such as cancer and neurodegenerative diseases.
Mouse
A synthetic peptide, aa 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein.
2D2
IgG1
Human and Monkey. Does not react with mouse and rat. Others not known.
Jurkat, K562, HL-60, or HeLa Cells. Reed-Sternberg cells in Hodgkin's lymphoma.
Recognizes a protein of 21kDa, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein.
Cytoplasmic
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