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Genebiosolution > IHC Primary Antibody > Bcl-2 (Apoptosis and Follicular Lymphoma Marker)

Bcl-2 (Apoptosis and Follicular Lymphoma Marker)

Clone 124 (Concentrate)

Expression of Bcl-2 alpha oncoprotein inhibits programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.

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Specifications

Species

Mouse

Immunogen

A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein

Clone

124

Isotype

IgG1, kappa

Species Reactivity

Human. Does not react with Mouse and Rat. Others not known.

Positive Control

Jurkat, K562, HL-60, or HeLa Cells. Tonsil or follicular lymphomas.

Specificity

This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein.

Status

RUO

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G0016RP

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