Bcl-2 Antibody (mouse monoclonal)

Bcl-2 Antibody ( Mouse Monoclonal )

The BCL-2 (B-cell lymphoma 2) Mouse Monoclonal Antibody, Clone 124 from GeneBioSolution is a premium-grade immunohistochemistry (IHC) antibody engineered for the specific and reliable detection of the BCL-2 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections. Designed to meet the demanding requirements of modern pathology laboratories, this antibody delivers high sensitivity, strong signal intensity, and reproducible staining for a wide range of diagnostic and research applications. BCL-2 is a key anti-apoptotic protein located primarily on the outer mitochondrial membrane, where it functions to inhibit programmed cell death. Dysregulation and overexpression of BCL-2 play a significant role in tumor development and therapy resistance, particularly in hematologic malignancies such as follicular lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma, chronic lymphocytic leukemia (CLL), and multiple myeloma, as well as in certain solid tumors. Clone 124 is one of the most widely validated and clinically utilized mouse monoclonal antibodies for BCL-2 detection, recognized for its robust and reproducible performance in routine pathology. The GeneBioSolution version is produced under ISO 13485-compliant manufacturing with rigorous lot-to-lot quality control, ensuring consistent results across batches. Validation includes testing on a broad panel of normal and neoplastic tissues, tissue microarrays, and multi-site performance evaluation. In IHC, Clone 124 produces a distinct granular cytoplasmic staining pattern in BCL-2-positive cells, with minimal background staining, facilitating precise interpretation. It is particularly valuable for distinguishing reactive follicular hyperplasia (BCL-2 negative in germinal centers) from follicular lymphoma (BCL-2 positive in germinal centers), a distinction critical for accurate lymphoma diagnosis.