Bcl-2 Antibody (Rabbit monoclonal)

Product Overview

The Bcl-2 Rabbit Monoclonal Antibody Clone E17 by GeneBioSolution is a highly specific reagent designed for immunohistochemical (IHC) detection of B-cell lymphoma 2 (BCL2) protein expression in human tissue samples. BCL2 plays a pivotal role in regulating apoptosis by inhibiting cell death, and its overexpression is often associated with various cancers, particularly lymphoid malignancies like follicular lymphoma and chronic lymphocytic leukemia. In these cancers, the BCL2 protein prevents apoptosis, contributing to tumor survival and progression. The Bcl-2 Clone E17 antibody is engineered to specifically recognize and bind to BCL2, offering high sensitivity and precision in IHC applications. This makes it a valuable tool in the diagnosis of lymphoma, as well as in identifying minimal residual disease in patients undergoing treatment. The antibody is particularly useful for differentiating between reactive and neoplastic follicular proliferation in lymph node biopsies and detecting low levels of tumor cells in bone marrow samples. Furthermore, Clone E17 has been shown to be more sensitive than traditional antibodies, such as Clone 124, in detecting BCL2 expression in certain diffuse large B-cell lymphoma (DLBCL) cases, enhancing diagnostic accuracy. It also aids in characterizing tumor subtypes and assessing the effectiveness of therapeutic interventions by identifying BCL2-negative cases that may require different treatment strategies. GeneBioSolution ensures the highest quality standards for this antibody, with rigorous validation through Western blot analysis, immunohistochemical staining, and lot-to-lot consistency checks. The Bcl-2 Rabbit Monoclonal Antibody Clone E17 is available in a liquid, ready-to-use form and is stored at 2–8°C. Its high specificity and ability to detect BCL2 in formalin-fixed, paraffin-embedded tissues make it an indispensable tool for oncologists and pathologists working with lymphoma and other cancer types. With its reliability and precision, this antibody provides crucial diagnostic support for better-informed treatment decisions, particularly in oncology research and clinical diagnostics.