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Bcl-X (Apoptosis Marker) Antibody

The Bcl-X Apoptosis Marker Antibody is a highly specific antibody designed to detect Bcl-X, a key regulator of apoptosis, in human tissue samples using immunohistochemistry (IHC). Bcl-X plays a critical role in the regulation of cell death, with its isoforms Bcl-X_L and Bcl-X_S having opposing effects on apoptosis. Overexpression of Bcl-X_L has been linked to various cancers, as it can prevent apoptosis and promote tumor survival. This antibody provides accurate detection of Bcl-X expression, making it invaluable for cancer research and diagnostics. Ideal for studying apoptosis-related mechanisms in tissue samples, this antibody helps identify Bcl-X expression patterns, which can aid in the characterization of tumors and understanding their response to therapies. It is an essential tool for pathologists, researchers, and clinicians working with cancerous tissues, particularly those focusing on lymphoma, leukemia, and other malignancies where apoptosis dysregulation plays a crucial role in disease progression. The Bcl-X Apoptosis Marker Antibody is validated for use in IHC on formalin-fixed, paraffin-embedded tissues and is known for its high specificity and reproducibility. With its reliable performance, this antibody supports precise and consistent results in apoptosis-related studies, providing valuable insights into the underlying molecular mechanisms of cancer.

Specifications

Species

Mouse

Immunogen

A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein

Clone

2H12

Isotype

IgG2a

Species Reactivity

Human, Mouse, Rat, and Pig. Others not tested.

Positive Control

Jurkat, K562, HL-60, or HeLa Cells. Reed-Sternberg cells in Hodgkin's lymphoma.

Specificity

Recognizes a protein of 27kDa, identified as the Bcl-X protein. This MAb shows no cross-reaction with Bcl-2 or Bax protein. This MAb reacts with both Bcl-XS and Bcl-XL proteins.

Status

RUO

Ordering Information

Format:

Volume:

  • Classification
  • RUO
  • Catalogue Number
  • G0022RP