Brachyury Antibody
GR391/Rabbit/Monoclonal
Gene Bio Solution Brachyury Antibody. Gene bio solution’s rabbit recombinant antibody Brachyury, a T-box transcription factor that plays a vital role in early vertebrate development. In tumor cells, Brachyury induces epithelial-mesenchymal transition, an important step in progression toward metastasis. Brachyury can be used to distinguish chordoma from histologic mimics, including clear cell renal cell carcinoma, chondrosarcoma, chordoid meningioma.
Brachyury (T) is founding member of T box (Tbx) family and is a transcriptional activator expressed throughout the nascent mesoderm, tailbud and notochord. The Tbx gene family comprises members with a unique DNA binding domain. Tbx genes are a family of developmental regulators with more than 20 members recently identified among invertebrates and vertebrates. Mutations in Tbx genes have been found to cause several human diseases. The understanding of functional mechanisms of Tbx products has come mainly from the prototypical brachyury protein, a transcription activator. The T-domain is a highly conserved DNA-binding motif originally defined in brachyury and characteristic of the Tbx family of transcription factors. The murine brachyury gene is required in posterior mesoderm formation and axial development. Mutant embryos lacking brachyury gene function are deficient in notochord differentiation and posterior mesoderm formation but develop anterior mesoderm.
