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Genebiosolution > IHC Primary Antibody > c-Myc Oncoprotein

c-Myc Oncoprotein

Clone: 9E10.3

c-Myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-Myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.

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Specifications

Species

Mouse

Immunogen

A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from the C-terminus of human c-Myc, coupled to KLH.

Clone

9E10.3

Isotype

IgG1, kappa

Species Reactivity

Human. Does not react with Mouse, Rat, or Chicken. Others not tested.

Positive Control

HL-60 cells or breast carcinoma.

Specificity

This antibody recognizes a transcription factor of 64-67kDa, identified as c-Myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of the human c-Myc protein.

Cellular Localization

Nuclear

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G0226RP

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