The Caldesmon Antibody (Clone h-CALD) is a high-affinity monoclonal antibody specifically designed for the detection of high-molecular-weight caldesmon, a smooth muscle–specific actin-binding protein. This antibody is optimized for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues and serves as a reliable marker for smooth muscle differentiation. Widely used in diagnostic pathology, Caldesmon is essential for identifying smooth muscle tumors such as leiomyomas and leiomyosarcomas, and for distinguishing them from myofibroblastic or other soft tissue neoplasms. Clone h-CALD provides strong, specific cytoplasmic staining with minimal background, making it an indispensable tool for accurate tumor classification.
Mouse
Crude human uterus extract
h-CALD
IgG1, kappa
Human. Others not known.
Uterus
Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon.
Cytoplasm, Cytoskeleton, Myofibril, Stress fiber
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