The CD117 Antibody (Rabbit Monoclonal) is a high-affinity, highly specific antibody designed to detect CD117, also known as c-Kit, a crucial receptor tyrosine kinase involved in regulating cell survival, proliferation, and differentiation. CD117 is widely expressed on hematopoietic stem and progenitor cells, mast cells, melanocytes, and interstitial cells of Cajal, playing a pivotal role in normal hematopoiesis and tissue homeostasis. Aberrant expression or mutation of c-Kit is frequently observed in a variety of cancers, including gastrointestinal stromal tumors (GIST), melanoma, acute myeloid leukemia (AML), and mastocytosis, making CD117 an important biomarker for cancer diagnosis, prognosis, and therapeutic targeting. This rabbit monoclonal antibody provides superior sensitivity and specificity compared to many traditional antibodies due to the rabbit immune system’s enhanced ability to recognize unique epitopes. It is especially effective for immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissue sections, enabling clear and consistent staining of CD117-positive cells. In addition to IHC, this antibody is validated for flow cytometry, immunofluorescence (IF), and Western blot applications, making it a versatile tool for researchers studying hematopoietic stem cells, tumor biology, and cell signaling pathways. Researchers rely on this CD117 rabbit monoclonal antibody to accurately identify and quantify CD117 expression in complex tissue samples, facilitating investigations into stem cell populations, tumor microenvironments, and responses to targeted therapies such as tyrosine kinase inhibitors. The antibody’s proven performance in detecting c-Kit across various species enhances its utility in both basic research and translational studies. Key features of this antibody include high affinity binding, low background staining, and excellent reproducibility, making it suitable for rigorous scientific studies. Whether you are working in oncology, immunology, regenerative medicine, or developmental biology, this CD117 antibody supports detailed analysis of cell populations critical to your research goals.
RM359
RM359 reacts human CD117/c-Kit
A peptide corresponding to the C-terminus of human CD117/c-Kit
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
