The CD14 Antibody Clone EPR3653 (Rabbit Monoclonal) is a premium-quality, high-affinity antibody developed for the sensitive and specific detection of CD14 in formalin-fixed, paraffin-embedded (FFPE) tissue sections using immunohistochemistry (IHC). CD14, also known as Cluster of Differentiation 14, is a key pattern recognition receptor (PRR) involved in the innate immune response. It acts as a co-receptor for the detection of bacterial lipopolysaccharides (LPS) in conjunction with TLR4 and MD-2, and is primarily expressed on the surface of monocytes, macrophages, and to a lesser extent, granulocytes. Due to its essential role in pathogen recognition, inflammation, and immune system activation, CD14 is a valuable biomarker for studying immune infiltration, chronic inflammatory conditions, infectious diseases, and tumor immunology. This rabbit monoclonal antibody is carefully optimized for high-performance IHC staining, delivering crisp, specific membrane and cytoplasmic staining in CD14-positive cells across a range of tissue types. Its enhanced affinity and epitope recognition capabilities—characteristics of rabbit monoclonals—make it ideal for detecting low-abundance antigens and achieving low background staining even in highly processed FFPE samples. This makes it particularly useful in clinical pathology, translational research, and biomarker validation in human tissues. The CD14 Rabbit Monoclonal Antibody is a vital tool for researchers and clinicians aiming to identify and evaluate monocyte/macrophage infiltration in tissue microenvironments. It is frequently used in research related to autoimmune diseases, sepsis, atherosclerosis, tuberculosis, and cancer, where CD14 expression levels can provide insights into disease progression, prognosis, and immune landscape. It also supports multiplex IHC workflows and dual-staining protocols when used alongside other lineage-specific markers, helping to build a more comprehensive immunological profile within tissue samples.
GRM415
GRM415 reacts to human CD14
A peptide corresponding to the C-terminus of human CD14
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
