The CD146 Rabbit Monoclonal Antibody [Clone RM249] is a high-affinity, highly specific antibody designed for the sensitive detection of CD146 (also known as Melanoma Cell Adhesion Molecule, MCAM, or MUC18), a key cell adhesion molecule involved in vascular biology, tumor progression, and immune regulation. CD146 is primarily expressed on endothelial cells, pericytes, and activated T cells, and is upregulated in various tumor types, including melanoma, prostate cancer, breast cancer, and gliomas. The RM249 clone offers superior epitope recognition and signal clarity, making it ideal for high-resolution detection of CD146 in both normal and pathological tissues. Optimized for use in immunohistochemistry (IHC), especially with formalin-fixed paraffin-embedded (FFPE) tissue sections, this antibody also performs effectively in flow cytometry, immunofluorescence (IF), and Western blotting. The rabbit monoclonal format ensures strong signal intensity with minimal background staining, making it highly suitable for applications where sensitivity and specificity are critical—such as tumor vasculature mapping, angiogenesis studies, endothelial cell profiling, and tumor microenvironment research. This antibody is a powerful tool for investigating the role of CD146 in cell adhesion, migration, angiogenic signaling, and tumor metastasis. It supports both basic and translational research in cancer biology, vascular medicine, and immunology. Researchers commonly use CD146 as a marker to identify vascular endothelial cells, mesenchymal stem cells, and circulating tumor cells, particularly in studies focused on tumor invasion and metastasis. In summary, the CD146 Rabbit Monoclonal Antibody [Clone RM249] is a robust and versatile reagent that provides highly specific and reproducible detection of CD146, supporting a wide range of studies in tumor biology, vascular research, and immunopathology
RM249
RM249 reacts to human CD146 (Cell surface glycoprotein MUC18). This antibody may also react to mouse or rat CD146, as predicted by immunogen homology.
A synthetic peptide corresponding to the residues near C-terminus of human CD146
Immunohistochemistry (IHC) Western Blot (WB)
Human (Mouse, Rat)
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
