CD15 Antibody (Mouse monoclonal)

CD15 Antibody (Mouse Monoclonal)

The CD15 Antibody (Mouse Monoclonal, Clone MMA) is a highly specific and rigorously validated monoclonal antibody designed for the precise detection of CD15, a carbohydrate antigen also known as the Lewis X antigen. CD15 is predominantly expressed on the surface of granulocytes, including neutrophils, eosinophils, and some subsets of monocytes. This antigen plays a significant role in cell adhesion, migration, and immune response modulation. The Clone MMA has become a gold standard in both clinical diagnostics and research due to its exceptional sensitivity and specificity. CD15 expression is critically important in hematopathology, particularly as a diagnostic marker for Hodgkin lymphoma, where it is expressed on Reed-Sternberg cells and their variants, as well as in other hematologic malignancies such as some non-Hodgkin lymphomas and myeloid leukemias. The ability of Clone MMA to reliably detect CD15 on these cells makes it invaluable for accurate tumor classification, prognostic evaluation, and therapeutic decision-making. This mouse monoclonal antibody exhibits excellent performance in various applications including immunohistochemistry (IHC) and cancer research. It is optimized for use on both formalin-fixed paraffin-embedded (FFPE) tissues and fresh or frozen samples. The antibody provides strong, crisp membrane and cytoplasmic staining with minimal nonspecific background, ensuring clear visualization of CD15-positive cells. This enables researchers and pathologists to confidently identify granulocyte populations, study immune cell infiltration in inflamed or tumor tissues, and assess disease progression or response to therapy.