CD163 Antibody (Rabbit Monoclonal)

CD163 Antibody (Rabbit Monoclonal)

The CD163 Antibody (Rabbit Monoclonal, Clone RM371) is a premium-grade, high-affinity antibody developed for the specific and sensitive detection of CD163, a key surface receptor highly expressed on monocytes and M2-polarized macrophages. CD163, also known as the hemoglobin–haptoglobin scavenger receptor, plays a vital role in regulating inflammation, clearing hemoglobin complexes, and promoting tissue repair. Its expression is closely associated with anti-inflammatory responses and immune suppression, particularly in tumor microenvironments, chronic inflammatory diseases, and infectious conditions. Clone RM371 is a rabbit monoclonal antibody engineered to provide exceptional sensitivity and specificity, with robust performance across key immunodetection platforms, including immunohistochemistry (IHC), flow cytometry, and immunofluorescence (IF). It shows strong, reproducible membrane and cytoplasmic staining in formalin-fixed paraffin-embedded (FFPE) human tissue samples, enabling detailed visualization and quantification of CD163-positive macrophages in situ. The superior affinity of RM371 ensures high signal intensity with minimal background—ideal for both routine pathology and advanced immunological research. CD163 expression is increasingly studied in the context of the tumor microenvironment, where M2 macrophages contribute to immune suppression, angiogenesis, and tumor progression. It is also a valuable marker for evaluating inflammation in infectious diseases, such as tuberculosis and viral infections, as well as for monitoring macrophage activity in cardiovascular diseases and organ transplantation.