The CD19 Antibody (Rabbit Monoclonal, Clone EP169) is a premium, high-affinity antibody specifically engineered for the precise detection of CD19, a crucial transmembrane glycoprotein uniquely expressed on the surface of B lymphocytes during most stages of their maturation. CD19 serves as a pivotal co-receptor that enhances B-cell receptor (BCR) signaling, playing an essential role in B cell activation, proliferation, differentiation, and survival. Due to its selective expression, CD19 is a key biomarker for studies involving B-cell development, immune response, and hematologic cancers. Clone EP169 is a rabbit monoclonal antibody meticulously developed for outstanding specificity and binding affinity to human CD19, enabling accurate identification and quantification of B cells in a wide array of biological samples. This antibody performs excellently in multiple applications including immunohistochemistry (IHC) on both formalin-fixed paraffin-embedded (FFPE) and frozen tissue samples, flow cytometry, and immunofluorescence (IF). In IHC, EP169 produces crisp, strong membranous staining in lymphoid tissues such as lymph nodes, tonsils, and spleen, as well as in B-cell malignancies including B-cell lymphomas, chronic lymphocytic leukemia (CLL), and acute lymphoblastic leukemia (ALL). Widely utilized in diagnostic pathology, this antibody aids in the immunophenotyping of B-cell neoplasms, supporting accurate diagnosis, prognosis, and disease progression monitoring. Additionally, it is an invaluable tool in immuno-oncology research for studying tumor-infiltrating B cells and the tumor microenvironment. Given CD19’s critical role as a target antigen in cutting-edge CAR-T cell therapies for B-cell cancers, Clone EP169 is increasingly vital in translational research and preclinical studies driving new immunotherapeutic developments. Research Areas: Hematopathology and lymphoma diagnostics B-cell development and immunology Autoimmune disease research Tumor microenvironment and immuno-oncology CAR-T cell therapy development and monitoring
Humans; others not tested
Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Buffer with protein carrier and preservative
Store at 2ºC to 8ºC
Lymph node or tonsil
Membranous
IgG
Recombinant fragment of human CD19 protein (around aa 96-281)
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
