The CD27 Rabbit Monoclonal Antibody (Clone RM501) is a premium, high-affinity antibody developed for the specific and sensitive detection of CD27, a critical member of the tumor necrosis factor receptor superfamily (TNFRSF7) expressed on subsets of T lymphocytes, B lymphocytes, and natural killer (NK) cells. CD27 serves as a pivotal costimulatory molecule involved in T-cell activation, proliferation, survival, and the generation of memory immune responses. Due to its essential role in regulating adaptive immunity, CD27 is widely studied in contexts ranging from immune system disorders, autoimmune diseases, to hematological malignancies such as lymphomas and chronic lymphocytic leukemia (CLL). Clone RM501, generated using advanced rabbit monoclonal antibody technology, ensures exceptional specificity and high binding affinity to human CD27. This antibody has been extensively validated for use in multiple applications including immunohistochemistry (IHC) on formalin-fixed paraffin-embedded (FFPE) tissues, flow cytometry for detailed immune cell profiling, and in cancer research settings. In IHC, RM501 provides crisp, strong membranous and cytoplasmic staining patterns, facilitating clear identification of CD27-positive cells in lymphoid tissues, tumor biopsies, and peripheral blood. The CD27 Rabbit Monoclonal Antibody Clone RM501 is indispensable for researchers and clinicians aiming to investigate immune activation pathways, monitor disease progression, or evaluate therapeutic efficacy in immuno-oncology and autoimmune disease studies. Its robust performance and minimal background staining make it an ideal reagent for multiplex staining protocols, enabling comprehensive characterization of the tumor microenvironment and immune cell interactions.
RM501
RM501 reacts to human CD27 (TNFRSF7)
A peptide corresponding to residues near the C-terminus of human CD27
Immunohistochemistry (IHC); Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
