The CD276 antibody (rabbit monoclonal), clone RM335, is a high-affinity antibody specifically developed to detect CD276 (B7-H3), an immune checkpoint protein that plays a critical role in tumor immune evasion and T-cell regulation. CD276 is a type I transmembrane protein of the B7 family, often overexpressed in a wide range of solid tumors, including lung, breast, prostate, and colorectal cancers, while showing limited expression in normal tissues. Clone RM335 offers highly specific and sensitive detection of CD276 in immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tissues, and is ideal for use in cancer immunology research, biomarker discovery, and immunotherapy target validation. The rabbit monoclonal format provides enhanced signal-to-noise ratio and excellent tissue penetration, delivering strong membranous and cytoplasmic staining with minimal background. CD276 is increasingly recognized as a prognostic marker and a potential therapeutic target, making this antibody a valuable tool for translational research and pathology studies. Clone RM335 is validated on human tissues and is recommended for studies involving tumor microenvironment analysis, checkpoint blockade therapy, and immune response modulation.
RM335
RM335 reacts to the cytoplasmic domain of human CD276 (B7-H3).
A peptide corresponding to the C-terminus of human CD276 (B7-H3).
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
