CD278 (ICOS) Antibody (Rabbit Monoclonal, Clone RM417) is a highly specific and sensitive reagent designed for the detection of Inducible T-cell COStimulator (ICOS or CD278), a critical immune checkpoint molecule expressed primarily on activated T cells. ICOS is part of the CD28 superfamily and plays an essential role in T-cell activation, differentiation, cytokine secretion, and germinal center formation. As a key player in adaptive immunity, ICOS has emerged as an important biomarker in studies of autoimmunity, chronic inflammation, and especially in immuno-oncology, where it is being actively explored as a therapeutic target. Clone RM417 is a rabbit monoclonal antibody engineered for high-affinity and low-background detection of human ICOS in a wide range of research and diagnostic applications. This antibody has been rigorously validated for use in immunohistochemistry (IHC) on formalin-fixed paraffin-embedded (FFPE) tissues and cancer research. In IHC, RM417 yields strong, clear membranous and cytoplasmic staining of ICOS-positive T cells, making it ideal for profiling tumor-infiltrating lymphocytes (TILs) and studying T-cell responses within the tumor microenvironment. The CD278 (ICOS) Rabbit Monoclonal Antibody Clone RM417 is an invaluable tool for researchers investigating T-cell co-stimulatory pathways, immune checkpoint regulation, and the development of next-generation immunotherapies. Its superior specificity and sensitivity make it a powerful reagent for both preclinical and translational research in cancer immunology, infectious diseases, and autoimmune disorders.
RM417
RM417 reacts to inducible T-cell costimulatory CD278
A peptide corresponding to the C-terminus of human CD278
Immunohistochemistry (IHC)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
