CD31 / PECAM-1 (Endothelial Cell Marker)

Clone 1A10

CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially be a predictor of tumor recurrence.

Specifications

Species

Mouse

Immunogen

Prokaryotic recombinant fusion protein corresponding to a portion of the extracellular domain downstream of the signal sequence of the CD31 (PECAM-1).

Clone

1A10

Isotype

IgG1, kappa

Species Reactivity

Human. Others not known.

Positive Control

Tonsil, Angiosarcoma.

Specificity

Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare.

Status

RUO