CD35 Antibody (Rabbit Monoclonal)

CD35 Antibody (Rabbit Monoclonal)

The CD35 Antibody (Rabbit Monoclonal, Clone EP197) is a highly specific and sensitive antibody designed for the detection of CD35, also known as complement receptor 1 (CR1). CD35 is a membrane glycoprotein expressed on B cells, monocytes, macrophages, granulocytes, and follicular dendritic cells, and plays a crucial role in regulating the complement cascade by binding to C3b and C4b components. This makes CD35 a key marker in studying immune complex clearance, complement activation, and autoimmune regulation. Clone EP197 is a rabbit monoclonal antibody developed using advanced recombinant technology to ensure high affinity, low background, and consistent staining. It is optimized for use in immunohistochemistry (IHC) on formalin-fixed paraffin-embedded (FFPE) tissues, delivering clear and reproducible membranous and cytoplasmic staining in CD35-positive cells. It is particularly useful in identifying follicular dendritic cell networks in lymphoid tissues and in the classification of lymphomas, such as follicular lymphoma and nodular lymphocyte predominant Hodgkin lymphoma. This antibody is widely used in immunopathology, oncology, and immunology research, aiding in the analysis of germinal center architecture, immune regulation, and complement-mediated responses. Its high specificity makes it an excellent choice for differentiating reactive lymphoid hyperplasia from follicular neoplasms, and for assessing complement receptor expression in normal and diseased tissues.