The CD3E Antibody (Rabbit Monoclonal, Clone RM344) is a high-affinity, rigorously validated antibody developed for the precise detection of CD3 epsilon (CD3E), a key signaling subunit of the T-cell receptor (TCR) complex. Expressed on the surface of mature T lymphocytes, CD3E plays a central role in T-cell activation, antigen recognition, and immune signaling, making it an indispensable biomarker in immunology, hematopathology, and cancer immunotherapy research. Clone RM344, derived from rabbit monoclonal technology, offers enhanced sensitivity and specificity compared to traditional mouse antibodies. It delivers strong, crisp membranous staining of T cells in immunohistochemistry (IHC) using formalin-fixed paraffin-embedded (FFPE) tissues, and is equally effective in flow cytometry and immunofluorescence (IF) assays. It consistently marks T-cell populations in normal lymphoid tissues and pathologic conditions, including T-cell lymphomas, leukemias, and tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment. This antibody is a valuable tool for clinical diagnostics and translational research, supporting the identification of T-cell subsets, monitoring immune responses, and aiding in the evaluation of immunotherapeutic strategies and biomarker development. Key Features: Clone: RM344 Host Species: Rabbit Monoclonal Target Antigen: CD3E (CD3 epsilon) Applications: Immunohistochemistry (IHC) Flow Cytometry Immunofluorescence (IF) Sample Types: FFPE tissues, blood, lymphoid tissue, tumor biopsies Localization: Cell surface membrane of mature T cells Species Reactivity: Human (others upon validation) Research Areas: T-cell biology and immune signaling Hematopathology and lymphoma diagnostics Autoimmune disease and immune profiling Immuno-oncology and CAR-T therapy research The CD3E Rabbit Monoclonal Antibody, Clone RM344, is an essential reagent for precise, reliable, and reproducible T-cell detection across research and diagnostic workflows. Its high specificity and robust performance make it ideal for laboratories focused on T-cell immunophenotyping, immune monitoring, and oncology diagnostics.
RM344
RM344 reacts to the cytoplasmic domain of human CD3 epsilon chain.
A peptide corresponding to the C-terminus of human CD3 epsilon chain.
Immunohistochemistry (IHC) Western Blot (WB)
Human
None
Research Use Only
Stable for 1 Year at -20.0°C from date of receipt.
At Genebiosolution, our commitment lies in crafting cutting-edge solutions for researchers, clinicians, and diagnostic laboratories seeking excellence in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). With a focus on quality, reliability, and accuracy, our products empower advancements in molecular diagnostics and research methodologies.
