CD44 / HCAM is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion, and migration. It plays a key role in lymphocyte activation, recirculation, and homing, as well as in tumor metastasis. Clone 156-3C11 is a concentrated monoclonal antibody specifically developed for the detection of standard CD44 isoforms in formalin-fixed, paraffin-embedded tissues. It is commonly used as a marker in the study of a variety of tumors, including those of epithelial and hematopoietic origin.
Mouse
Stimulated human leukocytes
156-3C11
IgG2a, kappa
Human, Baboon, and Green Monkey. Others not tested.
HeLa cells or paracortex in tonsil or lymph node.
Recognizes a cell surface glycoprotein of 80-95kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leukocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin.
Cell surface