CD45 / LCA (Leukocyte Marker)

CD45 / LCA (Leukocyte Common Antigen) is a transmembrane protein tyrosine phosphatase expressed on most nucleated hematopoietic cells and is essential for antigen receptor signaling in lymphocytes. Clone 136-4B5 is a concentrated monoclonal antibody specifically designed for the reliable detection of CD45 in formalin-fixed, paraffin-embedded tissues. It serves as a robust pan-leukocyte marker and is widely used in diagnostic pathology to identify hematopoietic cells and to differentiate lymphoid malignancies from non-hematopoietic tumors.

Specifications

Species

Mouse

Immunogen

Stimulated human leukocytes

Clone

136-4B5

Isotype

IgG1, kappa

Species Reactivity

Human. Others not known

Positive Control

Ramos, U-698, or GA-10 cells. Tonsil

Specificity

CD45R, also designated as CD45 and PTPRC, has been identified as a transmembrane glycoprotein broadly expressed among hematopoietic cells. This antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms

Cellular Localization

Cell surface and cytoplasmic