CD45 / LCA (Leukocyte Marker)

CD45 / LCA (Leukocyte Common Antigen) is a transmembrane protein tyrosine phosphatase expressed on all nucleated hematopoietic cells, making it a reliable pan-leukocyte marker. It is essential for immune cell signaling and is widely used in immunohistochemistry to identify and classify hematopoietic tumors, such as lymphomas and leukemias. This marker is valuable in distinguishing hematopoietic neoplasms from non-hematopoietic tumors in diagnostic pathology.

Specifications

Species

Mouse

Immunogen

Stimulated human leukocytes

Clone

135-4C5

Isotype

IgG2b, kappa

Species Reactivity

Human. Others not known

Positive Control

Ramos, U-698, or GA-10 cells. Tonsil

Specificity

CD45R, also designated as CD45 and PTPRC, has been identified as a transmembrane glycoprotein broadly expressed among hematopoietic cells. This antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms

Cellular Localization

Cell surface and cytoplasmic