CD45RB is an isoform of the CD45 family, expressed on various hematopoietic cells, including memory B cells, subsets of T cells, monocytes, and granulocytes. It plays a key role in regulating immune cell activation and signaling. As a leukocyte marker, CD45RB is widely used in immunohistochemistry to identify and classify hematolymphoid cells, aiding in the diagnosis of lymphomas and other immune-related disorders.
Mouse
Human peripheral blood lymphocytes maintained in T-cell growth factor
PD7/26
IgG1, kappa
Human. Others not known
Ramos, U-698, or GA-10 cells. Tonsil
CD45R, also designated as CD45 and PTPRC, has been identified as a transmembrane glycoprotein broadly expressed among hematopoietic cells.
Cell surface and cytoplasmic