CD45RO (T-Cell Marker)

CD45RO is an isoform of the CD45 family, primarily expressed on memory T cells and a subset of B cells and monocytes. It plays a critical role in T-cell activation and signal transduction. Clone T200/797 is a concentrated monoclonal antibody specifically developed for the detection of CD45RO in formalin-fixed, paraffin-embedded tissues. This antibody is widely used in immunohistochemistry to identify memory T-cell populations and assist in the classification of lymphoid malignancies and other immune-related conditions.

Specifications

Species

Mouse

Immunogen

Recombinant human CD45RO protein

Clone

T200/797

Isotype

IgG2a, kappa

Species Reactivity

Human. Others not known

Positive Control

CCRF-CEM, Jurkat or MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node

Specificity

This antibody recognizes a 180-185kDa protein, identified as an isoform of leukocyte common antigen (CD45RO). It shows no reactivity with normal B-cells or natural killer cells, but reacts with granulocytes and monocytes.

Cellular Localization:

Cell surface