CD47, also known as Integrin Associated Protein (IAP), is a transmembrane protein broadly expressed on a wide range of cell types. It plays a crucial role in cell adhesion, migration, and immune evasion by interacting with signal regulatory protein alpha (SIRPα) to transmit a “don’t eat me” signal to macrophages. Clone CD47/2937 is a monoclonal antibody developed for the specific detection of CD47 in formalin-fixed, paraffin-embedded tissues. It is commonly used in research and diagnostic applications, particularly in studies of cancer, immune regulation, and cell signaling.
Mouse
A recombinant fragment (around aa 18-135) of human CD47 protein (exact sequence is proprietary)
CD47/2937
IgG2c
Human
MCF-7, Jurkat, Prostate, THP-1, U-87 cells
This antibody reacts with Ig domain of CD47 protein
Cell membrane, Cell surface