CD5 (Mantel Cell Lymphoma Marker) Antibody
Clone: 4C7
The CD5 antibody, clone 4C7, is a high-affinity mouse monoclonal antibody optimized for the sensitive and specific detection of CD5, a 67 kDa cell surface glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. CD5 is physiologically expressed on mature T lymphocytes, thymocytes, and a subset of B cells, particularly those involved in certain hematological malignancies. Clone 4C7 is widely recognized for its diagnostic value in immunohistochemistry (IHC), especially in identifying CD5-positive B-cell lymphomas, including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
This antibody exhibits strong, crisp membranous staining on formalin-fixed, paraffin-embedded (FFPE) tissues, allowing pathologists to accurately assess CD5 expression in lymphoid tissues. It is particularly useful for distinguishing MCL (CD5-positive, Cyclin D1-positive) from follicular lymphoma or marginal zone lymphoma, which are typically CD5-negative. In T-cell malignancies, CD5 staining helps confirm diagnoses such as peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL).
In normal tissues, clone 4C7 highlights T-cell zones in lymph nodes, the paracortical region of tonsils, and thymic cortex, making it a reliable control for T-cell presence. Due to its excellent specificity and minimal background staining, clone 4C7 is frequently used in diagnostic IHC panels in surgical pathology and hematopathology.
The CD5 (4C7) antibody is a critical tool in both clinical and research settings for studying lymphoid neoplasia, T-cell biology, and immune system dysregulation. Its robust performance makes it well-suited for use in routine diagnostic laboratories, academic research, and translational studies focused on immune profiling and cancer classification.
