Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species.
Mouse
Membrane preparation of a small cell lung carcinoma
123A8 (same clone as 56C04)
IgG1, kappa
Human. Others not known
Cerebellum, Pancreas, Neuroblastoma
This antibody targets the extracellular domain of CD56/NCAM, detecting its expression in most neuroectodermal tissues and tumors such as neuroblastomas, medulloblastomas, astrocytomas, and small cell carcinomas.
Cell surface