CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular “scavenger receptor cysteine-rich” (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T-cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T-cells and a subset of B-cells. Antibodies to CD6 are used to deplete T-cells from bone marrow transplants to prevent graft versus host disease.
Mouse
Human rheumatoid synovial T-cell line ST-1
3F7B5
IgG1
Human. Others not known
CCRF-CEM, Jurkat cells, Tonsil
Cell membrane positivity as expressed by thymocytes, mature/activated T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Cell surface and cytoplasmic