The CD8A Monoclonal Antibody [Clone C8/468] specifically detects CD8 alpha, a transmembrane glycoprotein expressed predominantly on cytotoxic T lymphocytes (CD8+ T cells), a key population involved in cell-mediated immunity. CD8A plays a crucial role in recognizing antigen presented by MHC Class I molecules and is essential for the elimination of infected or malignant cells. This antibody is ideal for identifying and quantifying cytotoxic T cells in tumor microenvironments, autoimmune diseases, transplant rejection, and infectious diseases.
Mouse
Human CD8 recombinant protein
C8/468
IgG1, kappa
Human. Others not known.
HuT78 or hPBL. Tonsil.
CD8 is a 68kDa transmembrane glycoprotein expressed as a heterodimer by a majority of thymocytes, and by major histocompatibility complex (MHC) class I restricted, mature, suppressor/cytotoxic T-cells.
Cell surface